Read e-book online Animal Models of Neurological Disease, I: Neurodegenerative PDF

By Ernest D. Olfert (auth.), Alan A. Boulton, Glen B. Baker, Roger F. Butterworth (eds.)

ISBN-10: 0896032086

ISBN-13: 9780896032088

ISBN-10: 1592596266

ISBN-13: 9781592596263

to the Animal types Volumes This and a number of other volumes within the Neuromethods sequence will describe a few animal types of neu- psychiatric problems. as a result of expanding public drawback over the moral therapy of animals in examine, we felt it incumbent upon us to incorporate this common preface to those volumes so as to point out why we expect extra examine utilizing animals is important and why animal types of psychi- ric and neurologic issues, specifically, are so very important. We realize that animals should still purely be used while appropriate possible choices are usually not on hand. we expect it self-e- dent, notwithstanding, that people can simply be experimented upon in critically proscribed situations and substitute seasoned- dures utilizing telephone or tissue tradition are insufficient in any types requiring exams of behavioral switch or of complicated in vivo techniques. in spite of the fact that, whilst the misery, pain, or ache to the animals outweighs the predicted earnings for human welfare, then the learn isn't really moral and shouldn't be carried out.

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Additional info for Animal Models of Neurological Disease, I: Neurodegenerative Diseases

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If the neurotoxin reaches the lateral hypothalamus, the rat may stop eating, and if the neurotoxin reaches the third ventricle, the rat usually dies during surgery. Although the precise cause has not been investigated rigorously, death may be owing to destruction of the vegetative centers in the floor of the fourth ventricle. The survival rate for this surgery can be greatly enhanced if the lesions are produced in two stages. In the first stage, the excitotoxin is injected into the basal forebrain in one or two places unilaterally.

The concentration and volume of the neurotoxin will influence the degree and anatomical extent of cholinergic cell loss in the basal forebrain. 4. , 1985). , 1986). The monkeys are prepared for aseptic surgery using standard procedure. Each monkey is premeditated with dexamethasone and ketamine, anesthetized with pentobarbital, placed in a stereotaxic instrument (David Kopf, Chicago, IL), and the skin, connective tissue, and muscle are incised and retracted to expose the skull. Trephine openings are placed bilaterally in the skull.

1982). , those involving lesions of the basal forebrain cholinergic system. 3. Choice of Lesion Methods The choice of lesion methods depends upon the nature and extent of the proposed lesion. , 1978). If fibers of passage as well as cell bodies and afferent terminals within a discrete region are intended to be destroyed, then application of electrical current Alzheimer’sDisease 39 through a metal electrode can be used to produce an extensive lesion. , electrolytic lesions) or injections of selective neurotoxins (for review, seeWenk and Olton, 1987).

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Animal Models of Neurological Disease, I: Neurodegenerative Diseases by Ernest D. Olfert (auth.), Alan A. Boulton, Glen B. Baker, Roger F. Butterworth (eds.)


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