By James E., Jr. Crowe, Diana Boraschi, Rino Rappuoli
State-of-the-art reports overlaying significant features of antibodies and intervention opposed to infectious diseases
The connection among antibodies and infectious ailments has spawned whole comparable fields of analysis. Antibodies for Infectious Diseases offers views from best learn scientists and summarizes the fantastic development during this zone right into a unmarried definitive resource.
Providing a huge survey of an important features of the sector of antibodies for infectious ailments, this book
- presents basic good points touching on constitution, functionality, isotype, and the position of supplement in antibody function
- examines the position of antibodies in antimicrobial immunity with particular targets
- details new tools for expression of monoclonal antibodies, in crops or via move of antibody genes for in vivo expression in taken care of subjects
Antibodies for Infectious Diseases is a complete reference for researchers, pharmaceutical builders, and overall healthiness care execs at the prestige of the improvement of antibody-based treatments for treating infectious ailments. it's also necessary as supplemental examining for top point existence sciences scholars.
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Extra resources for Antibodies for infectious diseases
19. 20. 21. 22. 23. HEY Wang Y, Das SR, O’Donnel CD, Yewdell JW, Subbarao K, Marasco WA, Mulligan M, Compans R, Ahmed R, Wilson PC. 2011. Broadly cross-reactive antibodies dominate the human B cell response against 2009 pandemic H1N1 influenza virus infection. J Exp Med 208:181–193. Köhler G, Milstein C. 1975. Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 256:495–497. Casadevall A, Dadachova E, Pirofski LA. 2004. Passive antibody therapy for infectious diseases.
In addition, organisms bound by complement can be internalized by phagocytic cells, with resultant clearance of the organism. Internalization through complement receptors on antigenpresenting cells can also result in the processing of antigen for presentation to T lymphocytes. The details of complement activation have been reviewed elsewhere (88). It is important to note that antibodies that bind and activate complement may also directly inhibit pathogens in the absence of complement. Complement activation may also have an indirect effect on pathogens by recruiting and activating leukocytes to sites of infection (89, 90).
2006. Recombinant human polyclonal antibodies: a new class of therapeutic antibodies against viral infections. Curr Pharm Des 12:2007–2015. Flego M, Ascione A, Cianfriglia M, Vella S. 2013. Clinical development of monoclonal antibody-based therapy drugs in HIV and HCV diseases. BMC Med 11:1–17. de Kruif J, Bakker ABH, Marissen WE, Arjen Kramer R, Throsby M, Rupprecht CE, Goudsmit J. 2007. A human monoclonal antibody cocktail as a novel component of rabies post-exposure prophylaxis. Annu Rev Med 50: 359–368.
Antibodies for infectious diseases by James E., Jr. Crowe, Diana Boraschi, Rino Rappuoli