Apoptosis and Autoimmunity: From Mechanisms to Treatments by Joachim R. Kalden, Martin Herrmann PDF

By Joachim R. Kalden, Martin Herrmann

ISBN-10: 0471239577

ISBN-13: 9780471239574

ISBN-10: 0471348899

ISBN-13: 9780471348894

ISBN-10: 3527303782

ISBN-13: 9783527303786

ISBN-10: 3527304428

ISBN-13: 9783527304424

This is often the 1st finished booklet in regards to the courting among apoptosis and autoimmune illnesses. It bargains a different up to date evaluate on learn effects at the faulty execution of apoptosis and the unfinished clearance of apoptotic cells. The molecular and mobile mechanisms concerned are defined intimately. As a potential final result of apoptotic disorder, the advance of serious autoimmune illnesses (e.g., rheumatoid arthritis, systemic lupus erythematosus) is mentioned. An outlook on destiny study subject matters comprises the assessment of novel healing innovations.

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Additional info for Apoptosis and Autoimmunity: From Mechanisms to Treatments

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During this stage, CD4/CD8 double-positive thymocytes that express TCR of intermediate affinity for peptide ligands in the context of MHC molecules differentiate into either CD4 or CD8 single-positive cells. T cells that express TCR with low affinity for peptide, however, fail to receive sufficient survival stimuli and die by neglect. On the other end of the spectrum from positive selection, an overly high-affinity TCR interaction with self-MHC causes Apoptosis and Autoimmunity. From Mechanisms to Treatments.

A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes. Nature 1992, 356, 768–74. Stennicke, H. R. and Salvesen, G. S. Catalytic properties of the caspases. Cell Death Different 1999, 6, 1054–9. , Kocher, H. , et al. Expression, refolding, and autocatalytic proteolytic processing of the interleukin-1 beta-converting enzyme precursor. J Biol Chem 1995, 270, 9378–83. Wilson, K. , Black, J. , Thomson, J. , Kim, E. , Griffith, J. , Navia, M. , Murcko, M. , Chambers, S.

S. and Dixit, V. M. An induced proximity model for caspase-8 activation. J Biol Chem 1998, 273, 2926–30. Kischkel, F. , Lawrence, D. , Arnott, D. and Ashkenazi, A. Death receptor recruitment of endogenous caspase-10 and apoptosis initiation in the absence of caspase-8. J Biol Chem 2001, 2, 2. , Srinivasula, S. , Alnemri, E. S. and Wang, X. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 1997, 91, 479–89. , Srinivasula, S. , Talanian, R.

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Apoptosis and Autoimmunity: From Mechanisms to Treatments by Joachim R. Kalden, Martin Herrmann

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