By Joachim R. Kalden, Martin Herrmann
This is often the 1st finished booklet in regards to the courting among apoptosis and autoimmune illnesses. It bargains a different up to date evaluate on learn effects at the faulty execution of apoptosis and the unfinished clearance of apoptotic cells. The molecular and mobile mechanisms concerned are defined intimately. As a potential final result of apoptotic disorder, the advance of serious autoimmune illnesses (e.g., rheumatoid arthritis, systemic lupus erythematosus) is mentioned. An outlook on destiny study subject matters comprises the assessment of novel healing innovations.
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Additional info for Apoptosis and Autoimmunity: From Mechanisms to Treatments
During this stage, CD4/CD8 double-positive thymocytes that express TCR of intermediate affinity for peptide ligands in the context of MHC molecules differentiate into either CD4 or CD8 single-positive cells. T cells that express TCR with low affinity for peptide, however, fail to receive sufficient survival stimuli and die by neglect. On the other end of the spectrum from positive selection, an overly high-affinity TCR interaction with self-MHC causes Apoptosis and Autoimmunity. From Mechanisms to Treatments.
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Apoptosis and Autoimmunity: From Mechanisms to Treatments by Joachim R. Kalden, Martin Herrmann