By Andras Perl
This choice of easily reproducible molecular innovations and comparable in vitro/in vivo version platforms can be utilized to discover the explanations of autoimmunity, in addition to how top it can be regulated. there are ways to evaluate immunological and biochemical pathways suitable for pathogenesis and to set up and determine quite a few autoimmune ailments, together with arthritis, lupus, diabetes, a number of sclerosis, myocarditis, thyroiditis, scleroderma, uveitis, and vitiligo.
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Additional info for Autoimmunity: Methods and Protocols
Some of the most convincing linkage results (Table 3) have been found by subgrouping the SLE families based on a specific autoimmune feature, for example, thrombocytopenia, hemolytic anemia, or diagnosis of rheumatoid arthritis. 3. Discussion and Future Directions We anticipate that family-based classical linkage analysis followed by the association-based positional cloning approach will continue to advance the understanding of the biology of SLE disease phenotypes by identifying the underlying susceptibility genes.
U S A 95, 9979–9984. 10. , White, R. , and Davis, R. W. (1980) Construction of a genetic linkage map in man using restriction fragment length polymorphisms. Am. J. Hum. Genet. 32, 314–331. 11. Weber, J. L. and May, P. E. (1989) Abundant class of human DNA polymor11 phisms which can be typed using the polymerase chain reaction. Am. J. Hum. Genet. 44, 388–396. 12. 12 Litt, M. and Luty, J. A. (1989) A hypervariable microsatellite revealed by in vitro amplification of a dinucleotide repeat within the cardiac muscle actin gene.
The strategy of using pedigree stratification as a way to discover linkage effects has only been pursued by our Oklahoma group. We have taken the advantage of a pedigree stratification strategy from our huge collection of pedigrees with relevant clinical and medical information available for each individual, especially for the patients with SLE. Therefore, the extraordinary clinical heterogeneity in lupus is consistent with this phenotype as a treasure trove of genetic linkages based on stratifying pedigrees by clinical or demographic features.
Autoimmunity: Methods and Protocols by Andras Perl